We conclude that it is possible to reach a credible reconstruction of the HTL without relying on a simple analogy with recent hunter-gatherers’ diets. The memory of an adaptation to a trophic level that is embedded in modern humans’ biology in the form of genetics, metabolism, and morphology is a fruitful line of investigation of past HTLs, whose potential we have only started to explore.
The paper you referenced is a theory, it’s not the evidence for the theory.
Like, I don’t know how you can take this seriously:
Another hypothesis claiming a human genetic predisposition to a carnivorous, low-carbohydrate diet is the “Carnivore Connection.” It postulates that humans, like carnivores, have a low physiological (non-pathological) insulin sensitivity. It allows prioritizing of glucose toward tissues like the central nervous system, erythrocytes, and testes that entirely or significantly depend on glucose, rather than muscles which can rely on fatty acids and ketosis instead (Brand-Miller et al., 2011); this sensitivity is similarly lower in carnivores (Schermerhorn, 2013). Brand-Miller et al. (2011) speculate that physiological insulin resistance allows humans on a low-carbohydrate diet to conserve blood glucose for the energy-hungry brain. The genetic manifestation of insulin resistance is complex and difficult to pinpoint to a limited number of genes (Moltke et al., 2014). However, Ségurel et al. (2013) found a significantly higher insulin resistance (low sensitivity) in a Central Asian population (Kirghiz) of historical herders, compared with a population of past farmers (Tajiks), despite both groups consuming similar diets. Their findings indicate a genetic predisposition to high physiological insulin resistance levels among groups consuming mainly animal-sourced foods. Additionally, a significant difference in the prevalence of this resistance exists between groups with long-term exposure to agriculture and those that do not, such as Australian aborigines, who have higher resistance. If higher physiological insulin resistance is indeed ancestral, its past endurance suggests that high carbohydrate (starch, sugar) consumption was not prevalent.
To put it simply, if the theory was correct, it would be visible in the high powered epidemiological data and various large studies, unless you’re implying that humans evolved a lot more since this paleo time.
The article is full of little pet theories and speculations that would take a few books to debunk piece by piece. Good luck.
https://doi.org/10.1002/ajpa.24247
Do you have a better source?
Try understanding the limits of the science.
For example adds some nice nuance.
The paper you referenced is a theory, it’s not the evidence for the theory.
Like, I don’t know how you can take this seriously:
To put it simply, if the theory was correct, it would be visible in the high powered epidemiological data and various large studies, unless you’re implying that humans evolved a lot more since this paleo time.
The article is full of little pet theories and speculations that would take a few books to debunk piece by piece. Good luck.