• Hildegarde@lemmy.blahaj.zone
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      4 hours ago

      Oral estrogen. They went and trans’d themselves.

      Grapefruit interacts badly with many medications. There are a lot of drugs that warn against having grapefruit while taking them. Oral estrogen is one, and taking hormones is a choice to be yourself far more than anything else.

      You’re on 196 on Blahaj. If you read something you don’t understand 87% of the time its transgender.

    • d5273@lemmy.world
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      11 hours ago

      Grapefruit is an enzyme inhibitor that blocks clearance of many pharmaceuticals. That’s dangerous as it can lead to accidental overdoses despite taking the right dosage.

      The person here ‘being themselves’ needs a 'script to deal with modern society and can’t have grapefruit as a result.

      • TerHu@lemmy.dbzer0.com
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        9 hours ago

        I know that your interpretation is most likely what they meant in this meme.

        However, I‘m wondering. Is there HRT that you take orally that could be affected by grapefruit too?
        In that case there could be a much more positive interpretation of them being told to just be themselves, and they started HRT to achieve exactly that.

        • Zron@lemmy.world
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          5 hours ago

          Ask your doctor or pharmacist if you can eat grapefruit while on medication.

          Grapefruit delays the breakdown of medication in the body. Most medication require the liver to break down whatever is in the pill into the actual chemical that will effect your body. So what happens is the original chemical in the meds builds up in your body’s and then the grapefruit wears off and your liver goes nuts making active ingredients, leading to an overdose.

        • d5273@lemmy.world
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          9 hours ago

          I’m not following your question… Grapefruit inhibits the breakdown of meds, it’s probably important to appropriately dose HRTs over days/weeks or else there could be some problems with the endocrine systems due to unexpectedly elevated levels (e.g. cardio stuff).

  • Hotstillnasty@lemmy.world
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    14 hours ago

    FYI [https://pmc.ncbi.nlm.nih.gov/articles/PMC3589309/] Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions. Recently, however, a disturbing trend has been seen. Between 2008 and 2012, the number of medications with the potential to interact with grapefruit and cause serious adverse effects (i.e., torsade de pointes, rhabdomyolysis, myelotoxicity, respiratory depression, gastrointestinal bleeding, nephrotoxicity) has increased from 17 to 43, representing an average rate of increase exceeding 6 drugs per year. This increase is a result of the introduction of new chemical entities and formulations.

  • lath@piefed.social
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    12 hours ago

    The problem with grapefruit is that it enhances the effects variably, which can lead to an unexpected overdose.